Clinicopathological features of carcinoma in situ in the background of breast infiltrating epithelisis:a report of nine cases
Objective To investigate the histopathology and immunohistochemical features of carcinoma in situ in the background of breast infiltrating epithelisis(IE),and to discuss its diagnosis and differential diagnosis.Methods Nine cases were collected,and estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER-2),Ki-67 and other items were detected by automatic immunohistochemistry.Results All 9 cases were middle-aged and elderly women with multiple nodules.Under the microscope,the epithelium showed hyperplasia,forming irregular epithelial nests,lacking lobular structural features,forming infiltrating morphology,which could involve the surrounding adipose tissue and nerve envelope.Myoepithelium was present in all cases,but in the sclerosing area,myoepithelium was reduced.Conclusion In the case of carcinoma in situ in the background of IE,when the feature of absence of lobular structure is similar to the infiltrating form,it is easy to be overdiagnosed as invasive carcinoma.At the same time,the cancer is often more extensive,so it is recommended to enlarged or simple mastectomy,and the possibility of bilateral breast cancer should be considered.
Infitrating epithelisisCarcinoma in situ of breastFalse infiltrationLack of lobular structureMyoepithelial reduction or absence
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