Midline structures ganglioglioma and ventricle ganglioglioma:a clinicopathologic study and review of literature
Objective To investigate the clinicopathological characteristics,molecular features of midline structures ganglioglioma and ventricle ganglioglioma.Methods The data of clinical features,immunophenotype and molecular biological tests result were collected.Results Microscopically,gangliogliomas were composed of abnormal neurons and glial cells with neoplastic hyperplasia.Immunohistochemically,the tumor cells showed positivity with GFAP,Olig-2,NeuN,MAP2.Most common mutation were BRAFV600E mutation.In gangliogliomas lacking BRAFV600E mutations,other oncogenic mutations in the BRAF gene were often present.Most patients had excellent prognosis.Conclusion Gangliogliomas that occur in midline structures or ventricle are rare.When you find a low-grade neuroepithelial tumors that occur in atypical sites,the diagnosis of ganglioglioma should be taken in consideration.The precise diagnosis shouId be confirmed by morphology,immunohistochemistry and necessarily molecular biological tests.
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