Calcifying fibrous tumor of the gastrointestinal tract:a clinicopathological analysis of 17 cases
Objective To investigate the clinicopathological features,immunophenotype,diagnosis and differential diagnosis of calcifying fibrous tumor(CFT)of the gastrointestinal tract.Methods We collected 17 gastrointestinal CFT cases,analyzed their clinical and pathological characteristics,and reviewed relevant literature.Results There were 13 females and 4 males.The age ranged from 16 to 67 years.Fifteen tumors were located in the stomach and 2 in the rectum.Microscopically,the tumor was characterized by a large amount of hyalinized collagen fibers interspersed with mildly distributed spindle cells,accompanied by infiltration of lymphocytes and plasma cells,variable amounts of dystrophic calcifications and psammoma bodies.Immunohistochemically,the tumor cells were positive for CD34(3/15)and SMA(1/16),but negative for DOG1,CD117,Desmin,S-100 and ALK.Conclusion CFT of the gastrointestinal tract is a rare benign fibrous tumor,which is easily misdiagnosed as other mesenchymal tumors derived from the digestive tract.Comprehensive analysis of pathological morphology and immunohistochemistry is necessary for the diagnosis.
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