Extranodal NK/T cell lymphoma with aberrant CD20 expression:a case series and literature review
Objective To explore the morphology,diagnostic pearls,and differential diagnoses of extranodal NK/T cell lymphoma with aberrant CD20 expression.Methods The morphologic features and immunohistochemical profile of three cases of extranodal NK/T cell lymphoma with aberrant CD20 expression were analyzed.Differential diagnoses were discussed,and a literature review was conducted.Results Extranodal NK/T cell lymphomas with aberrant CD20 expression were morphologically similar to the classic extranodal NK/T lymphoma.Immunohistochemically,they were positive for several T cell markers,and they were also positive for CD56,EBER ISH,and cytotoxic markers.Two of the three cases showed CD8 expression.CD20 demonstrated weak to moderate staining.Other B cell markers,such as CD79a and PAX-5,were negative.Conclusion Extranodal NK/T-cell lymphoma with aberrant CD20 expression is a rare form of lymphoma originating from NK cells.A comprehensive analysis of the immune profile,including the staining pattern,and careful differential diagnosis are essential to reach a correct diagnosis.
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