Anaplastic multiple myeloma:a clinicopathological analysis of three cases
Objective To investigate the clinicopathological features of anaplastic multiple myeloma(AMM).Methods The pathological morphology,immunophenotypes and molecular pathological characteristics of 3 AMM cases diagnosed at the Department of Pathology,Beijing Chaoyang Hospital Affiliated to Capital Medical University from 2017 to 2022 were analyzed.Results Two cases were males,and one was female.Among them,two cases were presented with multiple bone destruction.One case was presented with compression symptoms caused mainly by extramedullary lesions.Histologically,the tumor was composed of immature plasma cells with obvious atypia.Polymorphous,singular,and multinucleated cells were seen in some areas.Some nucleoli were seen.Immunohistochemistry showed that CD38,CD138 and MUM1 were diffuse positive,while CD20 and CD79α were negative.Immunoglobulins were expressed with Lambda chain restriction.Molecular testing showed high-risk cytogenetic abnormalities,mainly involving 1q21 gene amplification.Conclusion AMM is relatively rare,with obvious pleomorphism in histological morphology,and needs to be differentiated from various tumors.It has high-risk cytogenetic abnormalities and invasive disease progression,which requires high attention from clinicians and pathologists.
NETL
NSTL
万方数据
