Centrally necrotizing carcinoma of the breast:a clinicopathological analysis of seven cases
Objective To investigate the clinicopathological characeristics of centrally necrotizing carcinoma of the breast(CNC).Methods Seven cases of centrally necrotizing carcinoma of the breast were studied by HE and immunhistochemical staining.Results There were 7 cases of centrally necrotizing carcinoma of the breast,all female,accounting for 1.1％of the 636 cases of breast cancinoma in the same period.Their ages at the onset of the illness were 32 to 77 years(average 58 years).The duration of the illness before operation were 10 days to 3 years,71.4％(5/7)was located in the upper quadrant outside the left breast,and 28.6％(2/7)was located on the right side,all of which were single lesions.The main clinical symptoms were painless masses,and 57.1％(4/7)had a history of progressive enlargement of masses.Microscopically,the tumour was characterized by a large necrotic or accellular area in the center of the tumor,and a small amount of cancerous tissue remaining in the margin of the tumor,which was arranged in a stripe-like or nested patten.Immunohistochemical study of 7 cases(100％)showed positive E-cad,5(71.4％)showed positive CK5/6,4(57.1％)showed positive P63,and 7(100％)ki-67 had index ≥30％.Conclusion Centrally necrotizing cancinoma of the breast is an invasive cancer with unique structural characteristics,which is relatively rare,the correct understanding of this tumor can avoid undiaosis or misdiagnosis.
Breast neoplasmsCentrally necrotizingHistomorphologyImmunohistochemistryClinicopathology
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