Cervical monoclonal plasma cell proliferation:a clinicopathological analysis of two cases and review of literature
Objective To explore the clinicopathological characteristics,immunohistochemical characteristics,molecular characteristics and the prognosis of two cases of cervical monoclonal plasma cell proliferation.Methods We performed clinical and imaging analyses,morphological analyses,immunohistochemical staining,and molecular detection in two cases of cervical monoclonal plasma cell proliferation.Results Morphologically,the cervical mucosa was diffusely infiltrated with plasma cells of diverse maturity and some multinucleate cells in case one of a 23-year-old female.The cervical stroma was diffusely infiltrated with atypical cells with plasmacytoid differentiation in case two of a 37-year-old female.Both cases showed no radiographic abnormalities,but light chain restriction and clonal immunoglobulin gene rearrangement.No therapy was carried out,and no discomfort was recorded during the follow-up.Conclusion Cervical monoclonal plasma cell proliferation is a rare lymphomatoid disease,with light chain restriction expression and clonal immunoglobulin gene rearrangement.It is easily misdiagnosed as extramedullary plasmacytoma resultsing in overtreatment.The prognosis of this disease is favorable,and follow-up after local resection is recommended.
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