Expression of FN1 and PROS1 in papillary thyroid carcinoma with concomitant Hashimoto thyroiditis and their significance
Objective To investigate the clinical significance of FN1 and PROS1 expression in papillary thyroid carcinoma(PTC)concomitant with Hashimoto thyroiditis(HT).Methods Immunohistochemistry was used to detect the expression of FN1 and PROS1 in 114 cases of PTC with concurrent HT and 81 cases of HT alone,the clinicopathological features and the correlation between them were analyzed.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of FN1,PROS1 and their combination in PTC with HT.Results The positive rates of FN1 and PROS1 in PTC with HT were significantly higher than those in HT(P＜0.001).The expression of FN1 and PROS1 was correlated with lymph node metastasis(P＜0.05).Spearman analysis showed that the expression levels of FN1 and PROS1 were positively correlated in PTC tissues with HT(r=0.398,P＜0.001).ROC curve analysis showed that the PTC combined HT sensitivity of FN1,PROS1 and their combined detection was 95.06％,88.89％and 90.12％,and the specificity was 91.23％,92.11％and 95.61％,respectively.Conclusion FN1 and PROS1 are highly expressed in PTC tissues complicated with HT,and their positive expression is related to lymph node metastasis,which has high auxiliary diagnostic value for PTC complicated with HT.
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