Primary ependymoma in pelvic and abdominal cavity:a clinicopathological analysis and review of literature
Objective To provide a comprehensive overview of clinicopathological features,differential diagnosis,treatment,and prognosis of primary ependymoma in the pelvic and abdominal cavity.Methods This study summarizes one consultation case diagnosed in Peking Union Hospital and reviews 30 cases of primary ependymoma in the pelvis and abdominal cavity from the literature.Results We presented a 34-year-old woman with a well-defined weak echo mass in the left iliac fossa detected through B-ultrasound examination.The patient underwent cytoreductive surgery in another medical facility.During surgical exploration,a solid mass was found in the left iliac fossa that had a complete envelope and medium texture.Upon microscopic examination,the tumor exhibited a unique arrangement characterized by a sieve-like,solid,papillary,and adenoid pattern.Ependymal rosettes and rare mitotic figures were also observed.Immunohistochemical analysis revealed a dot-like perinuclear expression for EMA and D2-40 in the tumor cells,along with varying degrees of positivity for GFAP,ER,PR,PAX-8,S-100,and WT-1.Conclusion Primary pelvic and abdominal ependymomas are rare and typically observed in young women,which may lead to misdiagnosis.Immunohistochemistry typically exhibits positive results for ER,PR,WT-1,and PAX-8.Common treatments include surgery and adjuvant chemotherapy.While this tumor tends to recur,the associated mortality rate remains low.
Pelvic and abdominal cavityEpendymomaClinicopathological featuresImmunohistochemistryClinical features
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