摘要
目的 探讨成人原发胃Burkitt淋巴瘤(APSBL)的临床及病理特征.方法 收集首都医科大学附属北京朝阳医院病理科2017-02-2023-11诊断的APSBL共6例,总结其临床特征、组织学形态、免疫表型和荧光原位杂交(FISH)并对预后进行随访.结果 6例APSBL均为男性,平均年龄37.3岁;均为溃疡型病变,直径3～13cm;5例为经典BL形态学特征;肿瘤细胞均表达CD20、CD10、bcl-6,Ki-67均大于90％,C-myc均大于80％,bcl-2均为阴性;Mum-1在2例(2/6)中表达;5例行EBER原位杂交染色均阴性;6例均检测到MYC基因断裂,未检测bcl-2和bcl-6基因断裂;4例得以随访,随访时间为6～75个月,均无病生存.结论 APSBL较为罕见,病理诊断需结合临床症状、组织学形态、免疫表型及FISH检测综合判断.
Abstract
Objective To investigate the clinical and pathological features of adult primary gastric Burkitt lymphoma(APSBL).Methods A total of 6 cases of APSBL diagnosed in the Department of Pathology,Beijing Chaoyang Hospital,Capital Medical University from February 2017 to November 2023 were collected.The clinical features,histological morphology,immunophenotype and fluorescence in situ hybridization(FISH)result were summarized,and the prognosis of the patients was followed up.Results All the 6 patients with APSBL were male,with an average age of 37.3 years.5 cases were characterized by typical BL morphology.Tumor cells consistently expressed CD20,CD10 and bcl-6,Ki-67＞90％,C-myc＞80％,and bcl-2 was negative.Mum-1 was expressed in 2 cases(2/6).EBER in situ hybridization staining was negative in 5 cases.MYC gene rearrangements were detected in all 6 cases,lacking bcl-6 and bcl-2 gene rearrangements.Four of the six cases of APSBL were followed up for 6-75 months,and all of them were disease-free.Conclusion APSBL is relatively rare,and pathological diagnosis requires a comprehensive assessment based on clinical symptoms,histological morphology,immune phenotype,and FISH testing.
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