Clinicopathological features of adult primary gastric Burkitt lymphoma:report of six cases
Objective To investigate the clinical and pathological features of adult primary gastric Burkitt lymphoma(APSBL).Methods A total of 6 cases of APSBL diagnosed in the Department of Pathology,Beijing Chaoyang Hospital,Capital Medical University from February 2017 to November 2023 were collected.The clinical features,histological morphology,immunophenotype and fluorescence in situ hybridization(FISH)result were summarized,and the prognosis of the patients was followed up.Results All the 6 patients with APSBL were male,with an average age of 37.3 years.5 cases were characterized by typical BL morphology.Tumor cells consistently expressed CD20,CD10 and bcl-6,Ki-67＞90％,C-myc＞80％,and bcl-2 was negative.Mum-1 was expressed in 2 cases(2/6).EBER in situ hybridization staining was negative in 5 cases.MYC gene rearrangements were detected in all 6 cases,lacking bcl-6 and bcl-2 gene rearrangements.Four of the six cases of APSBL were followed up for 6-75 months,and all of them were disease-free.Conclusion APSBL is relatively rare,and pathological diagnosis requires a comprehensive assessment based on clinical symptoms,histological morphology,immune phenotype,and FISH testing.
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