Expression and significance of CK20 and Cathepsin K in renal eosinophilic tumors
Objective To investigate the expression and significance of CK20 and Cathepsin K in renal eosinophilic tumors.Methods Retrospective analysis of 155 cases of renal tumors with eosinophilic cell morphology was conducted.There were 34 chromophobic renal cell carcinoma eosinophilic subtypes,17 renal eosinophilic tumors,16 translocative renal cell carcinoma associated with microocular malformation,6 eosinophilic solid cystic renal cell carcinoma,5 renal epithelioid angiomyolipoma,4 renal low-grade eosinophilic tumors,3 renal cell carcinoma with fumarate hydratase deficiency,and 6 unclassified eosinophilic tumors.The expression of CK20 and Cathepsin K in 44 papillary renal cell carcinoma type Ⅰ and 20 clear cell renal cell carcinoma was studied as controls.Results The expression of CK20 and Cathepsin K was similar in these tumors,showing high positive rates in multiple eosinophilic renal tumors,and negative and low expression in control group.Conclusion CK20 and Cathepsin K lack specificity in the diagnosis of renal tumors associated with eosinophilic morphology and cannot be used as specific markers for a specific type including eosinophilic solid cystic renal cell carcinoma.However,the simultaneous positive of both antibodies can provide a preliminary classification of eosinophilic renal tumors and facilitate further analysis and diagnosis
Renal TumorEosinophilic cell morphologyCK20Cathepsin K
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