Comparison of friage value between three different technical methods in cervical cancer screening
Objective To explore the application and diagnostic value Thinprep cytologic test(TCT),DNA quantitative DNA analysis and human papillomavirus(HPV)detection in cervical cancer screening.Methods In this paper,using histopathological findings as the gold standard,and their diagnostic accuracy,sensitivity,specificity,positive predictive value and negative predictive value were compared and analysed by three screening method,namely TCT,quantitative DNA analysis and HPV testing.Results Of the 300 cases,the pathological diagnosis was cervical inflammation in 131 cases,117 were low-grade squamous intraepithelial lesions(LSIL),43 were high-grade squamous intraepithelial lesions(HSIL),and 9 were squamous epithelial cell carcinoma(SCC).The diagnostic sensitivity of TCT was 92.90％,specificity was 88.55％,accordance rate was 91.00％;the diagnostic sensitivity of DNA was 95.86％,specificity was 91.60％,accordance rate was 94.00％;the diagnostic sensitivity of HPV was 97.63％,specificity was 81.68％,accordance rate was 90.67％;the diagnostic sensitivity of TCT+HPV was 98.22％,specificity was 80.92％,accordance rate was 90.67％;the diagnostic sensitivity of DNA+HPV was 99.41％,specificity was 81.68％,accordance rate was 91.67％.The results of the working characteristic curve(ROC)analysis were AUC(HPV)＞AUC(DNA)＞AUC(DNA+HPV)＞AUC(TCT+HPV)＞AUC(TCT).Conclusion Screening with both TCT+HPV and DNA+HPV combination tests reduces the rate of missed diagnoses but increases the rate of misdiagnosis.The use of primary screening for HPV and quantitative DNA analysis for triage will be more accurate than screening for all three tests individually.
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