Primary lymphoepithelial carcinoma of lungs:a clinicopathological analysis of seven cases
Objective To investigate the clinicopathological features of primary lymphoepithelial carcinoma of lungs(PLECL).Methods The clinicopathology profiles of 7 cases of PLECL diagnosed from June 2016 to October 2022 in Department of Pathology,the First Affiliated Hospital of Hainan Medical University were reviewed and analyzed.Results There were 1 male and 6 females,with the age at presentation ranging from 33 to 63 years(mean 49 years;median 50 years).Five patients presented with a mass on the outer fields of the lungs on X-ray,two patients presented with a central mass.Microscopically,tumor cells arranged in nests or scattered in a diffused pattern with pale or eosinophilic cytoplasm and may have syncytial features with ill-defined cytoplasmic borders.The nuclei can be round,oval,or elongated,and have vesicular or finely granular chromatin with a distinct eosinophilic nucleolus.Stromal lymphocytes and plasma cells infiltrated were obvious.All tumor showed strong and diffuse immunohistochemical staining of CK pan,frequently expression of CK5/6,p63 and p40(5 of 7,respectively),but were negative for CK7,TTF-1,NapsinA.Ki-67 index ranged from 20％-80％.All tumors showed viral particle by in situ hybridization for Epstein-Barr virus-encoded small RNA.Conclusion PLECL tends to occur among the middle-aged and can be misdiagnosed as other carcinoma due to the overlap among them.EBER detection is helpful for diagnosis
NETL
NSTL
万方数据
