慢性淋巴细胞性/桥本氏甲状腺炎合并甲状腺原发性淋巴瘤6例的临床病理学分析并文献复习
Chronic lymphocyte/hashimoto's thyroiditis complicated with primary thyroid lymphoma:a clinicopathological analysis of six cases and review of literature
董双双 1田秀春 1王翠梅 1徐清 1肖芹 1顾学文1
作者信息
- 1. 扬州大学/临床医学院,江苏省苏北人民医院病理科,江苏扬州 225000
- 折叠
摘要
目的 探讨甲状腺慢性淋巴细胞性/桥本氏甲状腺炎合并淋巴瘤的临床病理特征.方法 回顾性收集6例患者临床及病理学特征,随访并复习相关文献.结果 6例患者,女性占5/6,患者年龄49～69岁,患者均存在甲状腺或颈部肿块病史,部分患者近期肿块增大,B超示甲状腺组织内不均质低回声.术后病理检查示弥漫大B细胞淋巴瘤,血管内大B细胞淋巴瘤,黏膜相关淋巴组织结外边缘区B细胞淋巴瘤,其中1例患者见乳头状癌.结论 慢性淋巴细胞性/桥本氏甲状腺炎合并甲状腺原发性淋巴瘤罕见,好发于中老年女性,临床症状、影像学多无特征性改变,需结合临床、影像和病理特征进行诊断.
Abstract
Objective To investigate the clinicopathological features,immunophenotype,differential diagnosis and prognosis of chronic lymphocyte/Hashimoto's thyroiditis associated with lymphoma.Methods The clinical features and pathomorphology of 6 patients were reviewed,follow-up wae performed,and relevant literature was reviewed.Results Six patients(5 females),aged 49-69 years,had a history of thyroid/neck mass,some of which had been enlarged rapidly recently.B-ultrasonography showed heterogeneous hypoechoic lesions in the thyroid.Postoperative pathological examination showed that all 6 cases were B-cell lymphoma,including 3 cases of diffuse large B-cell lymphoma and 2 cases of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue,1 case of intravascular large B-cell lymphoma,of which 1 case was associated with thyroid papillary carcinoma.Conclusion Chronic lymphocyte/Hashimoto's thyroiditis associated with primary thyroid lymphoma is a rare disease.It usually occurs in middle-aged and elderly women,it is easy to miss or misdiagnose,and the final diagnosis needs the combination of clinical,imaging and pathology.
关键词
慢性淋巴细胞性/桥本氏甲状腺炎/甲状腺原发性淋巴瘤/临床病理学特征/免疫组织化学Key words
Chronic lymphocyte/Hashimoto's thyroiditis/Primary thyroid lymphoma/Clinicopathological characteristics/Immunohistochemistry引用本文复制引用
基金项目
江苏省重点专科资金(ZDZKB0018)
江苏省苏北人民医院科研重点基金项目(SBKY21004)
出版年
2024
NETL
NSTL
万方数据