Chronic lymphocyte/hashimoto's thyroiditis complicated with primary thyroid lymphoma:a clinicopathological analysis of six cases and review of literature
Objective To investigate the clinicopathological features,immunophenotype,differential diagnosis and prognosis of chronic lymphocyte/Hashimoto's thyroiditis associated with lymphoma.Methods The clinical features and pathomorphology of 6 patients were reviewed,follow-up wae performed,and relevant literature was reviewed.Results Six patients(5 females),aged 49-69 years,had a history of thyroid/neck mass,some of which had been enlarged rapidly recently.B-ultrasonography showed heterogeneous hypoechoic lesions in the thyroid.Postoperative pathological examination showed that all 6 cases were B-cell lymphoma,including 3 cases of diffuse large B-cell lymphoma and 2 cases of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue,1 case of intravascular large B-cell lymphoma,of which 1 case was associated with thyroid papillary carcinoma.Conclusion Chronic lymphocyte/Hashimoto's thyroiditis associated with primary thyroid lymphoma is a rare disease.It usually occurs in middle-aged and elderly women,it is easy to miss or misdiagnose,and the final diagnosis needs the combination of clinical,imaging and pathology.
NETL
NSTL
万方数据
