Diagnostic value of HPV testing,liquid-based cytology and p16/Ki-67 triple detection in screening for cervical high-grade lesions
Objective To explore the diagnostic value of HPV testing,liquid-based cytology(LBC),and p16/Ki-67 triple testing in screening for high-grade cervical lesions.Methods A total of 1 839 cases of cervical biopsies from our pathology department during the years 2021-2022 were collected.A retrospective analysis was conducted to examine the detection rates of CIN2+using HPV testing,LBC,and p16/Ki-67 triple staining.The differences between the groups were compared to identify an efficient and specific detection method.Results Among the 1 839 cervical biopsy cases,the overall detection rate of CIN2+was 29.6％.The detection rates of CIN2+increased in the following order:HPV positive only(20.1％),HPV positive and LBC positive(32.3％),and HPV,LBC,and p16/Ki-67 triple positive(54.1％).Subgroup analysis showed that for HPV16/18 positive cases,the detection rates of CIN2+were 24.4％,45.7％,and 70.4％in the three groups,respectively.For the other 12 high-risk HPV types,the CIN2+positive detection rates were 14.6％,27.4％,and 45.3％in the three groups,respectively.Both overall and subgroup analyses demonstrated that the detection rate of CIN2+was highest with the HPV,LBC,and p16/Ki-67 triple staining,and the differences were statistically significant(P＜0.001).Conclusion This study suggests that for women who test positive for HPV,it is advisable to perform HPV,LBC,and p16/Ki-67 triple staining to increase the detection rate of CIN2+and to reduce missed diagnoses,thereby improving the utilization efficiency of colposcopy.
Precancerous lesions of the cervixHuman papillomavirusLiquid-based cytologyp16/Ki-67 dual staining
NETL
NSTL
万方数据
