Relationship between density,maturity and clinicopathological features of tertiary lymphoid structure in colorectal cancer
Objective To explore the correlation between the density and maturity of tertiary lymphoid structures(TLS)in colorectal cancer(CRC)and clinicopathological features and mismatch repair(MMR)proteins.Methods A total of 116 cases of CRC resection were collected,and the density and maturity of TLS were evaluated and grouped to analyze the relationship between the density and maturity of TLS and clinicopathological features and MMR.Results In CRC,the positive rate of TLS was 84.48％(98/1 16),and there were significant differences in TLS density among different TNM stages,tumor sites,tumor differentiation,lymph node metastasis and MMR expression groups(P＜0.05).The density of TLS was correlated with maturity(r=0.321,P＜0.05).There were significant differences in TNM stage,tumor site and TLS maturity among different tumor differentiation groups(P＜0.05).The earlier the TNM stage,the higher the right half colon,the higher the tumor differentiation,the higher the TLS density and maturity ratio.The higher the TLS density,the higher the TLS maturity.Conclusion TLS density and maturity are closely related to TNM stage,histological grade,tumor location and other important clinicopathological factors,suggesting that TLS,as an important indicator of immune status,may play an important role in controlling tumor occurrence and development.
Tertiary lymphoid structureColorectal tumorImmunotherapyMismatch repair protein
NETL
NSTL
万方数据
