Pituitary neuroendocrine tumors with triple-negative definite lineage:a clinicopathological anal-ysis of 12 cases
Objective To explore pathological features and the clinical significance of triple-negative pituitary neuroen-docrine tumors(PitNETs)with specific lineages.Methods We collected data from 12 cases of triple-negative PitNETs di-agnosed at the First Affiliated Hospital of the USTC from October 2019 to October 2023.Clinical and pathological informa-tion was compiled for analysis.Results Among the 12 cases,there were 6 males and 6 females,with an average age of 52.2 years.Three cases were recurrent PitNETs,4 cases presented with headaches and visual impairment,and 5 cases were dis-covered during routine medical examinations.Magnetic resonance imaging revealed irregularly enhanced lesions with diame-ters ranging from 1.5 to 4.2 cm.Pathological diagnoses included 7 cases of SF1 lineage,4 cases of TPIT lineage,and 1 case of PIT1 lineage PitNETs.Immunohistochemistry showed negative expression for SF1,TPIT,and PIT1 in all 12 cases.Among the SF1 lineage cases,7 were positive for GATA-3,3 were partially positive for ER,and all 7 were positive for LH and FSH.In the TPIT lineage cases,1 was positive for GATA-3,all were negative for ER,and all were positive for ACTH.In the PIT1 lineage case,GATA-3 was negative,ER was negative,and PRL was positive.Conclusions Triple-negative Pit-NETs with specific lineages are a rare subtype,The clinical manifestations are invasive macroadenomas or giant adenomas,which are prone to recurrence and have a relatively poor prognosis,requiring close follow-up.These tumors are character-ized by the absence of transcription factors SF1,TPIT,and PIT1,while exhibiting hormone positivity.The SF1 lineage hor-mones LH and FSH are mainly misdiagnosed as zero-cell tumors,and differential diagnosis is needed.The correct identifica-tion of this type of tumor is of great significance for the accurate classification and clinical diagnosis and treatment of PitNETs.
万方数据
维普
