Pulmonary pleura metastasis from low-grade appendiceal mucinous neoplasm colliding with appendiceal neuroendocrine tumor:a clinicopathological features
Objective To investigate the clinicopathologic feature of pulmonary pleura metastasis from low-grade appendi-cal mucinous neoplasm(LAMN)colliding with appendiceal neuroendocrine tumor(ANET).Methods Clinicopathological data of pulmonary pleura metastasis from LAMN colliding with ANET was collected and analyzed by histomorphology,im-munohistochemistry and AB-PAS staining.Results Tumors were found in the appendix,omentum,peritoneum and pul-monary pleura.Microscopically,A large amount of mucus was found in the appendiceal cavity,and the inner wall was cov-ered with mucous cells.Local appendiceal mucosal muscle was missing,and tumor cells clung to sclerosed interstitium.The microscopic morphology of omentum and pulmonary pleura/peritoneal tumor was consistent with LAMN.The ANET cells were arranged in nests.The cytoplasm was eosinophilic,the nuclear chromatin was pepper salt.Immunohistochemistry results showed that CK20 and CDX2 were expressed in LAMN,pulmonary pleura/peritoneal and omental nodules,but PAX8,HNF4a or TTF-1 were not.AB-PAS(+).ANET expressed CgA,Syn and CD56,but did not express CDX2.Conclusion The pulmonary pleura metastasis from LAMN colliding with ANET has the characteristic histomorphology and immunophenotype.Timely and accurate diagnosis is of great significance for the treatment and prognosis of the patients.
万方数据
维普
