Clinicopathological features of crystal-storing histiocytosis in the digestive tract
Objective To investigate the clinical pathological features,differential diagnoses and the associated lesions of crystal-storing histiocytosis(CSH)of the digestive tract.Methods A case of crystal-storing histiocytosis developed in the stomach was reported and a literature review was performed.Results The lesion showed as a whitish plaque of mucosa of gastric body under the endoscope.Microscopically,the lamina propria of mucosa was markedly extensive with accumulation of histiocytes with abundant intracytoplasmic crystal inclusions,which showed restricted expression of kappa light chain,as well as the surrounding plasma cells.Molecular assay was performed and clonal gene rearrangement of Igκ was revealed.A diagnosis of MALT lymphoma with plasma differentiation,combined with CSH was made.Conclusion Crystal-storing histiocytosis of the digestive tract is rare and often associated with lymphoplasmacytic disorder.Once the diagnosis of CSH is made,checking for underlying neoplastic conditions by using histological,molecular and clinical methods is necessary.
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