Clinicopathologic diagnostic essentials of florid reactive lymphoid hyperplasia and lymphomas of the cerivx
Objective To explore the clinicopathological features,diagnosis and differential diagnosis of florid reactive lymphoid hyperplasia(FRLH)and lymphoma of the cervix.Methods Two cases of lymphoproliferative diseases of the cervix were analyzed.The final pathological diagnosis was made by combining morphology,immunohistochemistry,and clinical features.Results Case 1:A polypoid object was seen at the cervical orifice.Under the microscope,there was no infiltration of lymphoid tissue growth and no clonal BCR gene rearrangement.Therefore,it was diagnosed as FRLH.Case 2:Cervical enlargement and hypertrophy were barrel shaped,with unclear boundaries between the local area and the bladder,rectum,and adjacent vaginal tissues.Under the microscope,tumor necrosis was seen,invading the squamous epithelium and infiltrating downwards.Clonal BCR gene rearrangement was detected.So the final diagnosis was diffuse large B-cell lymphoma(non-germinal center B-cell origin).Conclusion The FRLH of the cervix is a benign lesion with high proliferative activity and conspicuous mitotic activity.In some cases monoclonal gene rearrangement may be seen,which may lead to the misdiagnosis of lymphoma;while diffuse large B-cell lymphoma of the cervix is a neoplastic lesion.These lesions overlap with each other in microscopic appearance,immunophenotype,and even gene rearrangement.Therefore,colposcopic and systemic findings need to be considered before a final diagnosis can be made when dealing with FRLH and lymphoma of the cervix.
万方数据
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