摘要
目的 探讨肺腺癌组织中 c-MET 水平与其肿瘤分期、病理分级、淋巴结转移及术后复发的相关性.方法 2020 年1 月至 2022 年 1 月期间我院胸心外科进行肺癌手术切除病例共 496 例,收集其中予以肺癌根治术的100 例患者的肺腺癌组织及癌旁组织蜡块,免疫组织化学检测c-MET蛋白的表达,收集所有患者的性别、年龄、TNM分期、吸烟史及IASLC分级,并进行随访.结果 c-MET蛋白在肺腺癌组织的表达显著高于癌旁组织,差异有统计学意义(Uc=5.801,P=0.001);c-MET的阳性表达与不同年龄、性别、吸烟史、N分期、M分期差异无统计学意义(χ2 年龄=3.021,P=0.0821;χ2 性别=0.601,P=0.438;χ2 吸烟=1.382,P=0.241;χ2 N分期=0.683,P=0.408;χ2 M分期=1.032,P=0.311);c-MET的阳性表达与TNM分期、T分期、IASLC分级差异有统计学意义(χ2 TNM分期=8.651,P=0.003;χ2 T分期=5.210,P=0.022;χ2 IASLC分级=9.031,P=0.011);c-MET阳性表达组的中位无病生存期为 14 月,阴性表达组为 31 月(χ2=9.271,P=0.009),c-MET阳性表达组的 2 年复发率为 75.13％,高于c-MET阴性表达组(χ2=8.091,P=0.013).结论 c-MET在肺腺癌组织中存在高表达,与TNM分期、T分期、IASLC分级密切相关,其表达水平和患者预后相关.
Abstract
Objective To investigate the correlation between c-MET level in lung adenocarcinoma tissue and its tumor stage,pathological grade,lymph node metastasis and postoperative recurrence.Methods From January 2020 to January 2022,a total of 496 cases of lung cancer resection were performed in the thoracic and cardiac surgery department of our hospital,and wax blocks of lung adenocarcinoma tissues and paracancer tissues were collected from 100 patients who underwent radical resection for lung cancer.The expression of c-MET protein was detected by immunohistochemical experiments,and the gender,age,TNM stage,smoking history and IASLC classification were recorded,with follow-up.Results The difference was statistically significant in the expression of c-MET protein in lung adenocarcinoma tissues and paracancerous tissues(Uc=5.801,P=0.001);There was no statistically significant difference in the positive expression of c-MET and different age,gender,smoking history,N stage,M staging(χ2 age=3.021,P=0.0821;χ2gender=0.601,P=0.438;χ2 smoking=1.382,P=0.241;χ2 N stage=0.683,P=0.408;χ2 M staging=1.032,P=0.311).The difference was statistically significant in the positive expression of c-MET and TNM staging,T staging,and IASLC classification(χ2 TNMstaging=8.651,P=0.003;χ2 Tstaging=5.210,P=0.022;χ2 IASLC classification=9.031,P=0.011);The median disease-free survival period of the c-MET positive expression group was 14 months,and the negative expression group was 31 months(χ2=9.271,P=0.009).The 2-year recurrence rate of the c-MET positive expression group was 75.13％,higher than that of c-MET Met negative expression group(χ2=8.091,P=0.013).Conclusion c-MET is highly expressed in lung adenocarcinoma tissue,which is closely related to TNM stage,T stage,and IASLC classification,and its expression level is correlated with patient prognosis.
维普
万方数据