Expression of CDK1 in synovial sarcoma and its significance
Objective To study the expression of cyclin-dependent kinase 1(CDK1)in synovial sarcoma(SS)tissues and to explore its prognostic value in SS.Methods A total of 37 cases diagnosed with SS at the Affiliated Hospital of Xuzhou Medical University from January 2010 to November 2021 were collected,with adjacent normal tissues as controls.Immunohistochemistry was used to detect the expression of CDK1 and to compare its expression between the SS group and the normal control group,as well as its relationship with the prognosis of SS.Results The positive expression rate of CDK1 protein in the SS group was significantly higher than that in the normal control group(P<0.05).The analysis of the correlation between the expression of CDK1 and clinical pathological parameters revealed a statistically significant difference in the expression of CDK1 between tumor grades and Ki-67 index groups(P<0.05).The Spearman correlation analysis showed a significantly positive correlation between CDK1 positivity intensity and Ki-67 index(P<0.05).Single-factor survival analysis showed that patients with CDK1≤2+had longer overall survival(OS)after surgery than patients with CDK1>2+.Patients with a Ki-67 index≤15％had longer OS after surgery compared to patients with>15％,and the difference was statistically significant(P<0.05).Multivariate survival analysis showed that patient gender,recurrence,and CDK1 expression could serve as independent prognostic factors for postoperative OS in SS patients(P<0.05).Conclusion Increased CDK 1 expression may play an important role in the development of SS,and CDK 1 antibody can be used as a potential prognostic marker for SS and provide a basis for individualized precision treatment.
万方数据
维普
