Relationship between neurofilament light chain protein levels and clinical characteristics in patients with Al-zheimer disease
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国家科技期刊平台
NETL
NSTL
万方数据
维普
目的 探讨阿尔茨海默病患者神经丝轻链蛋白(neurofilament light chain,NfL)与临床特点相关性.方法 分析2020年6月—2022年12月宁波市第二医院收治的58例阿尔茨海默病患者的临床资料为研究对象.检测58例阿尔茨海默病患者的神经丝轻链蛋白水平.Simoa法检测阿尔茨海默病患者神经丝轻链蛋白水平,探索神经丝轻链蛋白表达与临床因素的关联性.结果 58例患者中女性患者33例,NfL水平为(24.93±17.07)pg/ml;男性患者 24 例,NfL水平为(28.14±17.98)pg/ml,差异无统计学意义.不同文化程度与NfL水平分别为:文盲[(27.87±14.75)pg/ml(7/58)]、小学[(15.22±9.62)pg/ml(7/58)]、初中[(27.95±15.60)pg/ml(14/58)]、高中[(12.84±2.97)pg/ml(4/58)]、中专[(37.35±26.63)pg/ml(7/58)]、大专[(33.79±21.81)pg/ml(5/58)]、大学[(15.22±9.62)pg/ml(7/58)],结果无统计学差异.用相关分析研究NfL和年龄、病程、海马分级,日常生活活动能力评定量表(Activities of Daily Living,ADL)分值,简易精神状态检查表(Mini-Mental State Examination,MMSE)分值,长谷川痴呆量表(Hasegawa Dementia Scale,HDS)分值之间的相关关系,Pearson相关系数(r)表示相关关系的强弱情况.NfL和年龄的r值为0.448,提示NfL和年龄呈正相关.NfL和病程之间的r值为0.045,且P>0.05,说明NfL和病程无相关关系.NfL和海马分级的r值为0.345,说明NfL和海马分级有正相关关系.NfL和ADL分值之间的r值为0.242,P>0.05,说明NfL和ADL分值无相关关系.NfL和MMSE分值的相r值为‒0.099,P>0.05,说明NfL和MMSE分值无相关关系.NfL和HDS分值的r值为‒0.096,P值为 0.475>0.05,说明NfL和HDS分值之间没有相关关系.结论 阿尔茨海默病患者血清神经丝轻链蛋白水平与患者年龄,磁共振海马分级呈正相关,与性别、文化程度、病程、ADL分值、MMSE分值、HDS分值无相关关系.
Objective To investigate the relationship between neurofilament light chain protein(NfL)and clinical features in patients with Alzheimer disease.Methods We included 58 patients with Alzheimer's disease admitted to Ningbo No.2 Hospital from June 2020 to December 2021.NfL levels were measured for the 58 patients with Alzheimer's disease.Correlation analysis was performed to study the correlation between NfL and age,disease course,hippocampal grade,Activities of Daily Living(ADL)score,Mini-Mental State Examination(MMSE)score,and Hasegawa Dementia Scale(HDS)score.The Pearson correlation coefficient(r)represented the strength of correlation.Results Among the 58 patients,33 were females,with a mean NfL level of(24.93±17.07)pg/mL,and 24 were males,with a mean NfL level of 28.14±17.98 pg/mL,which were not significantly different.NfL levels for different educational attainments had no significant difference:illiteracy(7/58),(27.87±14.75)pg/mL;primary school(7/58),(15.22±9.62)pg/mL;middle school(14/58),(27.95±15.60)pg/mL;high school(4/58),(12.84±2.97)pg/mL;technical secondary school(7/58),(37.35±26.63)pg/mL;junior college(5/58),(33.79±21.81)pg/mL;and university(7/58),(15.22±9.62)pg/mL.NfL was positively correlated with age(r=0.448)and hippocampal grade(r=0.345),and not significantly correlated with the course of disease(r=0.045,P>0.05),ADL score(r=0.242,P>0.05),MMSE score(r=‒0.099,P>0.05),and HDS score(r=‒0.096,P>0.05).Conclusion Serum NfL levels in patients with Alzheimer disease are positively correlated with age and hippocampal grade on magnetic resonance imaging,but not associated with sex,education attainments,the course of disease,ADL score,MMSE score,and HDS score.
国家科技期刊平台
NSTL
万方数据
维普
