瘦素与围绝经期抑郁症的关系及研究进展
Research progress on the relationship between leptin and perimenopausal depression
崔文喆 1李广泉1
作者信息
- 1. 吉林大学第二临床医学院,吉林 长春 130062
- 折叠
摘要
围绝经期(perimenopausal period)是女性抑郁症高发期,常表现为情绪低落、心绪紊乱等抑郁症状,且发病基础尚不明确,亟待寻求好的治疗手段.瘦素是一种由脂肪组织分泌的激素,在新陈代谢和神经保护方面均发挥功能.近年来,瘦素被报道对围绝经期抑郁症具有一定的改善作用,且瘦素与雌激素的合成及分泌关系密切.因此瘦素可能成为治疗围绝经期抑郁症的潜在分子靶点.本文针对瘦素与围绝经期抑郁症的关系及相关研究进展进行综述.
Abstract
Perimenopausal period is a period with high incidence of female depression,which shows the symptoms of depressed mood and disturbed mind.The pathogenesis of the disease is not clear and it is urgent to search for efficient treat-ment.Leptin is a hormone secreted by fat cells and plays a role in both metabolism and neuroprotection.In recent years,leptin has been reported to ameliorate perimenopausal depression,and leptin is closely related to estrogen synthesis and se-cretion.Therefore,leptin may be used as a potential molecular target for the treatment of perimenopausal depression.In this paper,the research on the relationship between leptin and perimenopausal depression is reviewed.
关键词
抑郁症/围绝经期/瘦素/雌激素Key words
Depression/Perimenopausal period/Leptin/Estrogen引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据