Perimenopausal period is a period with high incidence of female depression,which shows the symptoms of depressed mood and disturbed mind.The pathogenesis of the disease is not clear and it is urgent to search for efficient treat-ment.Leptin is a hormone secreted by fat cells and plays a role in both metabolism and neuroprotection.In recent years,leptin has been reported to ameliorate perimenopausal depression,and leptin is closely related to estrogen synthesis and se-cretion.Therefore,leptin may be used as a potential molecular target for the treatment of perimenopausal depression.In this paper,the research on the relationship between leptin and perimenopausal depression is reviewed.
国家科技期刊平台
NSTL
万方数据
维普
