中风与神经疾病杂志2024,Vol.41Issue(2) :119-122.DOI:10.19845/j.cnki.zfysjjbzz.2024.0023

脑脊液抗GFAP抗体阳性的原发性中枢神经系统淋巴瘤1例报告

Primary central nervous system lymphoma with positive anti-GFAP antibody in cerebrospinal fluid:a case re-port

殷翔 关鸿志 任海涛 范思远 崔俐
中风与神经疾病杂志2024,Vol.41Issue(2) :119-122.DOI:10.19845/j.cnki.zfysjjbzz.2024.0023

脑脊液抗GFAP抗体阳性的原发性中枢神经系统淋巴瘤1例报告

Primary central nervous system lymphoma with positive anti-GFAP antibody in cerebrospinal fluid:a case re-port

殷翔 1关鸿志 2任海涛 2范思远 2崔俐1
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作者信息

  • 1. 吉林大学第一医院神经内科,吉林 长春 130021
  • 2. 北京协和医院神经内科,北京 100730
  • 折叠

摘要

本文报道1例原发性中枢神经系统淋巴瘤(PCNSL)病例.患者为青年男性,亚急性起病,病情迁延8月余,主要表现为逐渐加重的头痛及头晕,头部核磁影像提示脑室扩张、脑积水,脑膜强化;早期脱水降颅压后头痛症状可缓解;脑脊液中抗GFAP抗体阳性,经激素治疗后症状一度好转,然而激素减量后头痛症状再次加重;最终经脑脊液细胞学、脑脊液免疫细胞化学染色得以明确诊断PCNSL.

Abstract

This article reports a case of primary central nervous system lymphoma(PCNSL).The patient was a young man with subacute onset,and the disease lasted for more than 8 months and had the main manifestations of gradu-ally aggravated headache and dizziness.Cranial MRI showed ventricular dilatation,hydrocephalus,and meningeal en-hancement.Dehydration treatment aiming to reduce intracranial pressure alleviated the symptom of headache in the early stage of the disease;the cerebrospinal fluid was tested positive for anti-GFAP antibodies,and the symptoms were im-proved temporarily after hormone treatment.However,the symptom of headache aggravated again after hormone reduc-tion.Finally,the patient was diagnosed with PCNSL based on cerebrospinal fluid cytology and cerebrospinal fluid immuno-cytochemistry staining.

关键词

原发性中枢神经系统淋巴瘤/脑脊液细胞学/GFAP抗体

Key words

Primary central nervous system lymphoma/Cerebrospinal fluid cytology/Anti-GFAP antibody

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出版年

2024
中风与神经疾病杂志
吉林大学

中风与神经疾病杂志

CSTPCD
影响因子:0.754
ISSN:1003-2754
参考文献量5
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