Impact of cerebral microbleeds on the outcome of vascular recanalization in patients with acute cerebral infarc-tion
Objective To investigate the effects of cerebral microbleeds(CMB)on the prognosis of patients with acute cerebral infarction(ACI)treated with intravenous thrombolysis(IVT)or mechanical thrombectomy(MT).Methods A total of 738 patients with ACI treated with IVT or MT who were hospitalized in People's Hospital of Zhengzhou from January 2015 to June 2022 were consecutively included.They were evaluated for CMB at admission and the modified Rankin Scale(mRS)score at 3 months.The effects of the presence,location,and load of CMB on the mRS score at 3 months were analyzed.Subgroup analyses were performed for patients with successful recanalization.Results For all pa-tients,the presence or absence of CMB was not significantly associated with the 3-month prognosis(38.0%vs 44.2%,P= 0.295),while for the patients with successful recanalization,those without CMB had a significantly higher percentage of a favorable prognosis than those with CMB(56.9%vs 35.8%,P=0.011).The multivariable logistic regression analysis showed that for all patients,only high-load CMB was significantly associated with the prognosis at 3 months(odds ratio OR=0.017,95%confidence interval CI 0.112-0.808,P=0.017);in the patients with successful recanalization,the presence of CMB(OR=0.422,95%CI 0.214-0.832,P=0.013),lobar CMB(OR=0.379,95%CI 0.157-0.920,P= 0.032),and high-load CMB(OR=0.207,95%CI 0.056-0.760,P=0.018)were significantly associated with the 3-month prognosis.Conclusion The adverse effects of CMB for patients with successful recanalization are more marked as compared with patients with failed recanalization.The presence of CMB,lobar CMB,and high-load CMB are independent predictors of a poor outcome at 3 months in patients with successful recanalization.
万方数据
维普
