Value of the serum levels of ischemia-modified albumin and homocysteine in the diagnosis and disease assessment of white matter ischemic lesions
Objective To investigate the association of the serum levels of ischemia-modified albumin(IMA)and homocysteine(Hcy)with the onset and severity of white matter ischemic lesions(WMIL).Methods A total of 89 pa-tients who were diagnosed with WMIL by cranial magnetic resonance imaging(MRI)in our hospital from March 2020 to June 2022 were enrolled as WMIL group,and the volunteers with normal cranial MRI results,matched for sex and age,during the same period of time were enrolled as control group.The two groups were compared in terms of general informa-tion and laboratory markers,and the conditions of WMIL were evaluated and classified into mild and moderate-to-severe cases.A logistic regression analysis was used to investigate the influencing factors for the onset and severity of WMIL,and the receiver operating characteristic(ROC)curve was used to analyze the value of the serum levels of IMA and Hcy in the diagnosis of WMIL.Results Compared with the control group,the WMIL group had a significantly higher proportion of patients with hypertension or type 2 diabetes and significantly higher levels of uric acid(UA),IMA,and Hcy(P＜0.05).Compared with the control group,the WMIL group had a significantly higher proportion of the patients with moderate-to-severe WMIL who had hypertension or the proportion of type 2 diabetes,significantly higher levels of IMA and Hcy,and a significantly lower level of high-density lipoprotein cholesterol(P＜0.05).The logistic regression analysis showed that hy-pertension,elevated IMA level,and elevated Hcy level were influencing factors for the onset of WMIL(P＜0.05),and hy-pertension,elevated IMA level,and elevated Hcy level were influencing factors for the increase in WMIL severity(P＜0.05).The ROC curve analysis showed that serum IMA and Hcy had a certain value in the diagnosis of WMIL and moderate-to-severe WMIL.Conclusion Increases in the serum levels of IMA and Hcy are associated with the onset and aggravation of WMIL,and measurement of the serum levels of IMA and Hcy has a certain value in the diagnosis of WMIL and moderate-to-severe WMIL.
White matter ischemic lesionsIschemia-modified albuminHomocysteine
万方数据
维普
