Objective To investigate the non-motor symptoms of Parkinson disease in urban areas of Jilin Prov-ince,and explore the common types of non-motor symptoms and treatment plans,and to provide a scientific basis for re-searching the epidemiology and treatment of Parkinson disease in urban areas of Jilin Province.Methods We enrolled 90 patients with Parkinson's disease at the outpatient and inpatient departments of neurology of the Affiliated Hospital of Bei-hua University and the Affiliated Hospital of Jilin Medical University.They were randomly assigned into observation group and control group.A questionnaire was used to survey the two most common non-motor symptoms(anxiety and constipa-tion).The observation group was treated with Madopar combined with pramipexole,while in the control group,patients with anxiety received Madopar combined with sertraline hydrochloride,and those with constipation were given Madopar combined with lactulose and mosapride.The two groups were evaluated using non-motor symptom scales before and after treatment.Statistical analyses were performed.Results Anxiety and constipation were significantly resolved after 6 months of treatment with Madopar combined with pramipexole,and there were significant differences between the two groups(P＜0.05).Conclusion Madopar combined with pramipexole can effectively improve the motor symptoms and some non-motor symptoms of patients with Parkinson disease,delaying the progression of this disease as much as possible.
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维普
