Intracerebral hemorrhage(ICH)is a cerebrovascular disease with high morbidity,mortality,and disabil-ity.As hematoma is the key driver of brain injury after ICH,early removal of hematoma components is crucial for prevent-ing and reducing early brain damage following ICH.Existing treatments for ICH are limited in effectiveness,and recent preclinical trials have revealed some exciting findings,including an interesting new target—nuclear factor erythroid 2-re-lated factor 2(Nrf2).Nrf2 is a transcription factor that may play a neuroprotective role by activating cellular repair mecha-nisms through different pathways,and its therapeutic potential has attracted great interest in research.This article summa-rizes the role of Nrf2 and its agonists in post-ICH hematoma clearance and neuroprotection and the underlying mechanism.
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