认知功能障碍是1型发作性睡病(narcolepsy type 1，NT1)的常见症状之一，严重影响患者的学习工作。目前研究表明，NT1患者在注意力、记忆、执行功能等认知领域存在显著障碍。NT1认知功能障碍具体机制不明确，动物研究显示脑脊液食欲素分泌缺乏与认知障碍密切相关，同时近些年来神经影像学已结合不同的研究方法应用于NT1认知障碍机制的研究，能反映相关结构和功能异常。1型发作性睡病的认知功能障碍治疗至今仍缺乏有循证依据的治疗手段。本文对1型发作性睡病的认知功能障碍进展做一综述。
Research progress on cognitive dysfunction in narcolepsy type 1
Cognitive impairment is a common consequence of narcolepsy type 1(NT1),seriously affecting the pa-tients'learning and working.Research evidence has indicated that patients with NT1 exhibit substantial deficits in cogni-tive domains such as attention,memory,and executive function.The specific mechanisms underlying cognitive impair-ment in NT1 remain unclear.Animal studies have revealed a close association of insufficient orexin levels in cerebrospinal fluid with cognitive dysfunction.Recent neuroimaging studies with different methodologies have unraveled structural and functional abnormalities in cognitive dysfunction caused by NT1.To date,evidence-based treatment for NT1-associated cognitive impairment is still lacking.This article provides a review of the progress on cognitive impairment in NT1.
Narcolepsy type 1Cognitive dysfunctionOrexinFunctional magnetic resonance imaging
国家科技期刊平台
NSTL
万方数据
