Clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small ves-sel disease and their association with prognosis
Objective To investigate the clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small vessel disease(CSVD)and their association with prognosis.Methods A retrospective analysis was performed for the clinical data of the patients with hypertensive intracerebral hemorrhage who were hospitalized within 3 days after onset in Hebei Yanda Hospital from September 2017 to August 2021.Hematoma volume was calculated based on head CT scan results on admission;the severity of white matter hyperintensity,lacunae,enlarged perivascular spaces,and cerebral microbleeds was evaluated based on head MRI results after admission,and total CSVD score was calcu-lated.The clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of CSVD and their associa-tion with prognosis were analyzed.Results A total of 113 patients with cerebral hemorrhage were included,among whom there were 69 male patients and 44 female patients,with a mean age of(61.89±12.47)years.The univariate linear regression analysis showed that sex and systolic blood pressure were associated with bleeding volume,while total CVSD score was not asso-ciated with bleeding volume.The univariate linear regression analysis showed that hypertension,history of intracranial hemor-rhage,and total CVSD score were associated with NIHSS score on admission,and the multivariate logistic regression analysis showed that hypertension,history of intracranial hemorrhage,and total CVSD score were independent risk factors for high NIHSS score on admission.The univariate linear regression analysis showed that diabetes,smoking history,and total CVSD score were associated with MRS score on day 90 after discharge,and the multivariate logistic regression analysis showed that diabetes,smoking history,and total CVSD score were independent risk factors for poor prognosis.Conclusion The increase in total CSVD score may lead to the in-creases in the incidence rate of poor functional prognosis and NIHSS score on admission.
Hypertensive intracerebral hemor-rhageLoad of cerebral small vessel diseaseClinical featuresPrognosis
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