摘要
脑小血管病(CSVD)主要为小血管病变所引起的一系列临床、影像、病理综合征.CVSD起病隐匿,表现形式多样,早期识别率低,是逐渐发展为认知障碍的常见原因之一.值得注意的是,CSVD相关认知障碍不仅仅局限于血管性认知障碍,亦可累及阿尔茨海默病、帕金森病痴呆等其他神经退行性疾病.因此,精准识别、早期诊断和干预对控制CSVD相关认知障碍的发生及进展具有重要的价值.鉴于CSVD病理机制及分类繁杂,且其与认知障碍发展之间的关系不容忽视,本文在全面了解CSVD病因学、发病机制、病理及影像学表现进展的基础之上,对CSVD与多种认知功能障碍疾病的相关性进行综述,以期对CSVD相关认知功能障碍的临床多模评估和防治提供参考.
Abstract
Cerebral small vessel disease(CSVD)is a series of clinical,imaging,and pathological syndromes mainly caused by small vessel lesions,and it often has an insidious onset,diverse manifestations,and a low rate of early identification,which are the common reasons for gradual progression to cognitive impairment.It is worth noting that CSVD-related cognitive impairment is not limited to vascular cognitive impairment,and it can also involve other neurode-generative diseases such as Alzheimer disease and Parkinson disease dementia.Therefore,precise identification,early di-agnosis,and intervention are of great importance in controlling the development and damage of CSVD-related cognitive im-pairment.Given the complex pathological mechanisms and classifications of CSVD and the fact that the association be-tween CSVD and the progression of cognitive impairment cannot be neglected,this article provides a comprehensive under-standing of the etiology,pathogenesis,pathology,and imaging subtypes of CSVD and reviews the association between CSVD and various cognitive impairment diseases,so as to provide a reference for the clinical multimodal evaluation,pre-vention,and treatment of CSVD-related cognitive impairment.
基金项目
脑科学与类脑科学研究(2021ZD0201801)
脑科学与类脑科学研究(2021ZD0201808)
国家自然科学基金(81861138008)
国家自然科学基金(82011530139)
山东省自然科学基金(ZR2023QH019)
山东省立医院科研孵育基金(2022FY112)
国家科技期刊平台
NSTL
维普
万方数据