首页|脑小血管病与认知障碍的研究进展

脑小血管病与认知障碍的研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
脑小血管病(CSVD)主要为小血管病变所引起的一系列临床、影像、病理综合征。CVSD起病隐匿，表现形式多样，早期识别率低，是逐渐发展为认知障碍的常见原因之一。值得注意的是，CSVD相关认知障碍不仅仅局限于血管性认知障碍，亦可累及阿尔茨海默病、帕金森病痴呆等其他神经退行性疾病。因此，精准识别、早期诊断和干预对控制CSVD相关认知障碍的发生及进展具有重要的价值。鉴于CSVD病理机制及分类繁杂，且其与认知障碍发展之间的关系不容忽视，本文在全面了解CSVD病因学、发病机制、病理及影像学表现进展的基础之上，对CSVD与多种认知功能障碍疾病的相关性进行综述，以期对CSVD相关认知功能障碍的临床多模评估和防治提供参考。
Research advances in cerebral small vessel disease and cognitive impairment
Cerebral small vessel disease(CSVD)is a series of clinical,imaging,and pathological syndromes mainly caused by small vessel lesions,and it often has an insidious onset,diverse manifestations,and a low rate of early identification,which are the common reasons for gradual progression to cognitive impairment.It is worth noting that CSVD-related cognitive impairment is not limited to vascular cognitive impairment,and it can also involve other neurode-generative diseases such as Alzheimer disease and Parkinson disease dementia.Therefore,precise identification,early di-agnosis,and intervention are of great importance in controlling the development and damage of CSVD-related cognitive im-pairment.Given the complex pathological mechanisms and classifications of CSVD and the fact that the association be-tween CSVD and the progression of cognitive impairment cannot be neglected,this article provides a comprehensive under-standing of the etiology,pathogenesis,pathology,and imaging subtypes of CSVD and reviews the association between CSVD and various cognitive impairment diseases,so as to provide a reference for the clinical multimodal evaluation,pre-vention,and treatment of CSVD-related cognitive impairment.

Cerebral small vessel diseaseCognitive impairmentPathological mechanismsPrevention and treatment

张恒、杜怡峰

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山东第一医科大学附属省立医院,山东 济南 250021

脑小血管病 认知障碍 病理机制 防治

脑科学与类脑科学研究脑科学与类脑科学研究国家自然科学基金国家自然科学基金山东省自然科学基金山东省立医院科研孵育基金

2021ZD02018012021ZD02018088186113800882011530139ZR2023QH0192022FY112

2024

10.19845/j.cnki.zfysjjbzz.2024.0059

中风与神经疾病杂志
吉林大学

中风与神经疾病杂志

CSTPCD
影响因子：0.754
ISSN：1003-2754
年,卷(期)：2024.41(4)
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