摘要
脑小血管病(CSVD)是指各种病因影响脑内小动脉及其远端分支、微动脉、毛细血管、微静脉和小静脉所导致的一系列临床、影像、病理综合征.CSVD的病因复杂,起病隐袭,临床异质性大,可导致失能,严重危害人民健康及生命.近年来神经影像技术的发展极大地促进了CSVD的筛查及诊断,然而CSVD的有效治疗方法仍有限.本文将近年来有关CSVD的治疗现状及研究进展进行梳理和总结,包括传统治疗方法及潜在治疗靶点,对未来本领域可能的发展方向进行展望,旨在探索脑小血管病的有利治疗策略.
Abstract
Cerebral small vessel disease(CSVD)refers to a series of clinical,imaging,and pathological syndromes caused by various factors that affect intracerebral small arteries and their distal branches,arterioles,capillaries,venules,and small veins.CSVD has a complex etiology,an insidious onset,and significant clinical heterogeneity,which can lead to disability and greatly threatens the health and life of people.In recent years,the development of neuroimaging technol-ogy has greatly promoted the screening and diagnosis of CSVD,but there are still limited effective therapies for CSVD.This article reviews and summarizes the current treatment status and research advances in CSVD in recent years,including traditional treatment methods and potential therapeutic targets,and analyzes the future development directions in this field,so as to explore the effective treatment strategies for CSVD.
基金项目
大连市卫生健康委科技惠民项目(2111017)
大连市科技创新基金项目(2022JJ13SN084)
大连市重点学科"登峰计划"资助项目(FH2022003)
国家科技期刊平台
NSTL
维普
万方数据