Association between cerebral small vessel disease and mild cognitive impairment in the elderly
Objective To investigate the association between cerebral small vessel disease(CSVD)and mild cogni-tive impairment(MCI)in the elderly.Methods A total of 109 elderly patients who were diagnosed with MCI from March 2022 to February 2023 were enrolled as experimental group,and 89 healthy controls with normal cognitive function were en-rolled as control group.Demographic data and general clinical data were collected from all subjects,and the onset of CSVD was evaluated based on cranial MRI findings.The two groups were compared in terms of baseline data,general clinical data,and CSVD manifestations.The ordered multi-classification logistic regression model was used to identify the independent in-fluencing factors for MCI in the elderly.Results There were 109 patients with MCI and 89 controls in this study.Compared with the experimental group,the control group had significantly longer education years,a significantly better economic sta-tus,a significantly higher degree of participation in social activities,and a significantly lower alcohol consumption rate(P<0.05).There were 90 subjects(82.57%)in the experimental group and 62(69.66%)in the control group who had differ-ent CSVD phenotypes.The experimental group had significantly higher detection rates of LI and moderate-to-severe WMH than the control group(P<0.05),while there were no significant differences between the two groups in the detection rates of moderate-to-severe EPVS and CMB(P>0.05).There were significant differences between the two groups in the total load score of CSVD and the total load degree of CSVD(P<0.05).The logistic regression analysis showed that education years,participation in social activities,detection rate of CSVD,moderate-to-severe WMH,total load score of CSVD,and total load degree of CSVD were independent influencing factors for MCI in the elderly.Conclusion There is an increase in the detec-tion rate of CSVD in the elderly patients with MCI,especially LI and moderate-to-severe WMH.The total load score of CSVD and the total load degree of CSVD are independently associated with MCI in the elderly.
Cerebral small vessel diseaseMild cognitive impairmentElderlyInfluencing factors
国家科技期刊平台
NSTL
万方数据
维普
