AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告

A case report of anti-NMDAR and anti-AMPAR autoimmune encephalitis with opsoclonus-myoclonus syndrome

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国家科技期刊平台
NETL
NSTL
万方数据
维普

中文摘要：眼阵挛-肌阵挛综合征(OMS)是一种少见的神经系统综合征,与肿瘤相关,常见于儿童,成人少见,其特征是不自主、无节律、混乱、多向的眼球不自主运动,通常伴有四肢和躯干肌阵挛性抽搐、共济失调.抗α-氨基-3-羟基-5-甲基-4-异唑丙酸受体(AMPAR)与抗N-甲基-D-天冬氨酸受体(NMDAR)抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征的病例报道更为少见,对其临床表现及治疗缺乏全面的认识.现报道1例AMPAR与NMDAR抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征患者,并基于此病例对国内外相关文献进行复习,以期提高临床医生的认识.

外文摘要：Opsoclonus-myoclonus syndrome(OMS)is a rare neurological syndrome associated with tumors,which is more common in children than in adults.It is characterized by involuntary,arrhythmic,chaotic,multidirectional sac-cades,usually accompanied by limb and trunk myoclonic seizures and ataxia.Case reports are even rare on OMS compli-cated by autoimmune encephalitis with overlapping antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepro-pionic acid receptor(AMPAR)and N-methyl-D-aspartate receptor(NMDAR),and its clinical manifestations and treat-ment are poorly understood.We report a case of autoimmune encephalitis with OMS positive for both NMDAR and AMPAR antibodies,and also review relevant literature to help improve the understanding of the condition.

外文关键词：

Autoimmune encephalitisAlpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidN-methyl-D-aspartateLimbic encephalitisOverlap syndromeOpsoclonus-myoclonus syndrome

作者：

江佳佳、杨伊、王文暄、刘雅菁、尹梓曈、冯双浩、李小艳、卜晖

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作者单位：

河北医科大学第二医院,河北石家庄 050004

关键词：

自身免疫性脑炎 α-氨基-3-羟基-5-甲基-4-异唑丙酸 N-甲基-D-天冬氨酸边缘性脑炎重叠综合征眼阵挛-肌阵挛综合征

出版年：

2024

DOI：

10.19845/j.cnki.zfysjjbzz.2024.0072

中风与神经疾病杂志