AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告
A case report of anti-NMDAR and anti-AMPAR autoimmune encephalitis with opsoclonus-myoclonus syndrome
江佳佳 1杨伊 1王文暄 1刘雅菁 1尹梓曈 1冯双浩 1李小艳 1卜晖1
作者信息
- 1. 河北医科大学第二医院,河北 石家庄 050004
- 折叠
摘要
眼阵挛-肌阵挛综合征(OMS)是一种少见的神经系统综合征,与肿瘤相关,常见于儿童,成人少见,其特征是不自主、无节律、混乱、多向的眼球不自主运动,通常伴有四肢和躯干肌阵挛性抽搐、共济失调.抗α-氨基-3-羟基-5-甲基-4-异唑丙酸受体(AMPAR)与抗N-甲基-D-天冬氨酸受体(NMDAR)抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征的病例报道更为少见,对其临床表现及治疗缺乏全面的认识.现报道1例AMPAR与NMDAR抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征患者,并基于此病例对国内外相关文献进行复习,以期提高临床医生的认识.
Abstract
Opsoclonus-myoclonus syndrome(OMS)is a rare neurological syndrome associated with tumors,which is more common in children than in adults.It is characterized by involuntary,arrhythmic,chaotic,multidirectional sac-cades,usually accompanied by limb and trunk myoclonic seizures and ataxia.Case reports are even rare on OMS compli-cated by autoimmune encephalitis with overlapping antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepro-pionic acid receptor(AMPAR)and N-methyl-D-aspartate receptor(NMDAR),and its clinical manifestations and treat-ment are poorly understood.We report a case of autoimmune encephalitis with OMS positive for both NMDAR and AMPAR antibodies,and also review relevant literature to help improve the understanding of the condition.
关键词
自身免疫性脑炎/α-氨基-3-羟基-5-甲基-4-异唑丙酸/N-甲基-D-天冬氨酸/边缘性脑炎/重叠综合征/眼阵挛-肌阵挛综合征Key words
Autoimmune encephalitis/Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-D-aspartate/Limbic encephalitis/Overlap syndrome/Opsoclonus-myoclonus syndrome引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据