铁死亡的发生机制及其在脑出血中的作用与相关药物治疗研究进展
Research advances in the mechanism of ferroptosis,its role in intracerebral hemorrhage,and related drug thera-pies
魏阳阳 1王钦鹏 1蔡珂 1李婷婷 1梁成1
作者信息
- 1. 兰州大学第二临床医学院,甘肃 兰州 730000;兰州大学第二医院,甘肃 兰州 730030
- 折叠
摘要
铁死亡是一种新发现的、铁依赖性的非凋亡性细胞死亡方式,参与多种疾病的病理过程.脑出血是一种高发病率、高死亡率、高致残率的疾病,是神经科常见的急危重症,预后不良,极大地威胁人类的健康.脑出血引起的脑组织原发性损伤与细胞毒性、神经炎症、氧化应激等相关的继发性损伤是导致其预后不良的主要原因,其中,脑出血后继发性脑损伤是目前临床治疗的难点.研究表明,铁死亡与脑出血后继发性脑损伤的过程密切相关.深入研究脑出血后铁死亡的发生机制及其药物治疗的前景,将为脑出血后继发性脑损伤的诊治提供新思路和新靶点.
Abstract
Ferroptosis is a newly discovered iron-dependent form of non-apoptotic cell death and is involved in the pathological process of many diseases.Intracerebral hemorrhage is a disease with high morbidity,mortality,and disability rates and is a common acute and critical illness in the department of neurology,and it often has a poor prognosis and greatly threatens human health.Primary brain tissue injury caused by intracerebral hemorrhage and secondary injury asso-ciated with cytotoxicity,neuroinflammation,and oxidative stress are the main reasons leading to poor prognosis,among which secondary brain injury after intracerebral hemorrhage is a difficulty in clinical treatment at present.Studies have shown that ferroptosis is closely associated with the course of secondary brain injury after intracerebral hemorrhage.In-depth research on the mechanism of ferroptosis after intracerebral hemorrhage and the prospect of drug therapies will pro-vide new ideas and new targets for the diagnosis and treatment of secondary brain injury after intracerebral hemorrhage.
关键词
铁死亡/脑出血/继发性脑损伤Key words
Ferroptosis/Intracerebral hemorrhage/Secondary brain injury引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据