小胶质细胞在缺血性脑卒中进展过程中的作用及相关治疗
Role of microglial cells in ischemic stroke and related therapies
张达 1赵路清1
作者信息
- 1. 山西医科大学第五临床医学院神经内科,山西 太原 030000
- 折叠
摘要
脑卒中是导致人类残疾和死亡的重要疾病,具有较高的致残率和致死率.小胶质细胞作为中枢神经系统的重要组成部分,在病理刺激下可被诱导为M1、M2不同表型,发挥神经毒性与神经保护的双重作用.该文对小胶质细胞在缺血性脑卒中进展过程中的作用进行梳理,并探讨通过干预小胶质细胞治疗缺血性脑卒中的新靶点.
Abstract
Stroke is an important disease that leads to disability and death in humans and has relatively high disabil-ity and mortality rates.Microglial cells,as an important component of the central nervous system,can be induced into dif-ferent phenotypes of M1 and M2 by pathological stimulation and play a dual role of neurotoxicity and neuroprotection.This article reviews the role of microglial cells in the progression of ischemic stroke and explores the new targets for the treat-ment of ischemic stroke through intervention of microglial cells.
关键词
小胶质细胞/缺血性脑卒中/治疗Key words
Microglial cells/Ischemic stroke/Treatment引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据