Interpretation of the International League Against Epilepsy/American Epilepsy Society joint report on revisiting the concept of drug-resistant epilepsy
Despite the availability of novel anti-seizure medications(ASMs)in their third generation,one-third of the patients with epilepsy may progress to drug-resistant epilepsy(DRE).In 2010,the International League Against Epi-lepsy(ILAE)introduced the concept of DRE,which is still used today,and early diagnosis of DRE can facilitate timely preoperative evaluation for individuals with no response to ASMs,helping them to benefit from epilepsy surgery.Since the incidence rate of DRE remains high and there is a lack of update in related concepts,the ILAE/American Epilepsy Society(AES)Joint Translational Task Force discussed the heterogeneity,complexity,and dynamic changes of DRE manifesta-tions and mechanisms throughout the lifespan and across various species from the perspective of coordinating preclinical and clinical studies.The Joint Translational Task Force advocates the necessity of revisiting the current definition of DRE to enhance the clinical management of DRE,steer future research efforts towards DRE,and provide patients with more ef-fective and individualized treatment strategies,so as to reduce the incidence rate of DRE and improve the quality of life of patients.This article provides a concise overview and interpretation of the ILAE/AES report.
国家科技期刊平台
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