膳食炎症指数与罹患癫痫风险的关系研究——基于NHANES调查数据的横断面分析
Association between dietary inflammatory index and the risk of epilepsy:a cross-sectional analysis based on the National Health and Nutrition Examination Survey data
张玲 1陈邓 2刘凌2
作者信息
- 1. 四川大学华西医院神经内科,四川 成都 610041;成都市第八人民医院,成都医学院附属老年医院,四川 成都 610083
- 2. 四川大学华西医院神经内科,四川 成都 610041
- 折叠
摘要
目的 采用膳食炎症指数(DII)评估膳食炎症与罹患癫痫(EP)风险的相关性,为癫痫的防治工作提供饮食方面的科学依据.方法 采用2013年1月—2020年3月美国国家健康与营养检查调查(NHANES)收集的20岁及以上成年人数据.运用多元逻辑回归模型,分析DII与罹患癫痫风险的相关性,使用受限三次样条回归(RCS)进行线性试验,探索评分值与风险之间是否存在定量关系.通过亚组及交互作用分析,评估不同亚组之间DII和EP相关的稳定性.结果 研究纳入15 565例受访者,其中131例诊断为癫痫,在多元逻辑回归完全调整模型中,DII作为连续变量与罹患癫痫风险之间呈正相关(OR=1.12,95%CI 1.02～1.24;P=0.021);进行DII三分位后,在完全调整模型中,高促炎组的罹患癫痫风险高于低促炎组(OR=1.63,95%CI 1.02～2.6;P=0.039).在RCS线性试验中,DII与罹患癫痫风险之间呈正相关(非线性:P=0.342).在分层分析中,两者之间关系保持稳定,各亚组间未发现显著的交互作用.结论 美国成人DII与罹患癫痫风险呈正相关,DII每增加一个单位,癫痫发生风险增加12%.
Abstract
Objective To investigate the association between dietary inflammation and the risk of epilepsy(EP)based on dietary inflammatory index(DII),and to provide a scientific basis for the prevention and treatment of EP in terms of dietary intervention.Methods Related data of the adults aged≥20 years were obtained from the National Health and Nutrition Ex-amination Survey(NHANES)from January 2013 to March 2020.A multivariate logistic regression model was used to investi-gate the association between DII and the risk of EP,and a restricted cubic spline(RCS)regression analysis was used to per-form the linearity test and explore the quantitative relationship between DII score and the risk of EP.The subgroup and interac-tion analyses were used to evaluate the stability of the association between DII and EP across different subgroups.Results A total of 15565 respondents were included in this study,among whom 131 were diagnosed with EP.In the fully adjusted multi-variate logistic regression model,DII,as a continuous variable,was positively associated with the risk of EP[odds ratio(OR)=1.12,95%confidence interval(CI)1.02-1.24,P=0.021].After the tertile categorization of DII,the fully adjusted model showed that the high pro-inflammatory group had a significantly higher risk of EP than the low pro-inflammatory group(OR=1.63,95%CI 1.02-2.6,P=0.039).In the RCS linearity test,DII was positively associated with the risk of EP(non-linearity:P=0.342).The stratified analysis showed that the relationship between DII and the risk of EP remained stable,with no significant interactions observed between subgroups.Conclusion There is a positive correlation between DII and the risk of EP among American adults,and for every unit increase in DII,the risk of EP is increased by 12%.
关键词
癫痫/膳食炎症指数/促炎饮食/抗炎饮食Key words
Epilepsy/Dietary inflammatory index/Pro-inflammatory diet/Anti-inflammatory diet引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据