伴周围神经损害的抗SRP抗体及抗GT1a抗体双阳性免疫介导坏死性肌病1例报告
Immune-mediated necrotizing myopathy with positive anti-signal recognition particle antibody and anti-GT1a an-tibody accompanied by peripheral nerve injury:a case report
张忠胜 1黄嘉星 1孔学健1
作者信息
- 1. 广州医科大学附属第六医院(清远市人民医院)神经内科,广东 清远 511518
- 折叠
摘要
抗信号识别颗粒(SRP)坏死性肌病属于免疫介导坏死性肌病(IMNM)的一种类型.该病临床少见,起病隐袭,进展较快,主要表现为对称性四肢近端无力及肌酸激酶显著升高.本文报道1例合并周围神经病变的血清抗SRP抗体及抗GT1a抗体双阳性患者,分析其临床资料及诊治经过,以提高临床医生对该病的认识.
Abstract
Anti-signal recognition particle(SRP)necrotizing myopathy is a type of immune-mediated necrotizing myopathy(IMNM).It is a rare disease in clinical practice and has the features of insidious onset and rapid progression,with the main manifestations of symmetrical proximal limb weakness and a significant increase in creatine kinase.This ar-ticle reports a patient with positive serum anti-SRP antibody and anti-GT1a antibody accompanied by peripheral neuropa-thy and analyze related clinical data and diagnosis and treatment processes,in order to improve the understanding of this disease among clinicians.
关键词
信号识别颗粒/坏死性肌病/肢体乏力Key words
Signal recognition particle/Necrotizing myopathy/Limb weakness引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据