小胶质细胞中的脂滴在中枢神经系统疾病中的研究进展
Research advances in microglial lipid droplet in central nervous system disorders
李立琳 1胡敬龙 1徐运 1张梅娟1
作者信息
- 1. 南京大学医学院附属鼓楼医院,江苏 南京 210008
- 折叠
摘要
脂滴曾被简单认为是中性脂质的储存库,但最近的研究表明其在神经胶质细胞的信号转导、代谢和炎症中均发挥重要作用,尤其是在小胶质细胞中.小胶质细胞是中枢神经系统中常驻的单核吞噬细胞,与炎症、吞噬、髓鞘修复,以及衰老过程和神经系统变性疾病密切相关.然而,小胶质细胞内脂滴形成的机制以及对组织病理、相关疾病的影响仍有待阐明.在这篇综述中,我们总结了最近的研究结果,旨在进一步阐明这些问题.
Abstract
Lipid droplet were once simply regarded as depots for neutral lipids,but recent studies have shown that they play an important role in signal transduction,metabolism,and inflammation in glial cells,especially in microglia.Microglia are resident mononuclear phagocytes of the central nervous system and are closely associated with inflammation,phagocytosis,myelin repair,aging,and neurodegenerative diseases.However,further studies are needed to clarify the mechanism of lipid droplet formation in microglia and its influence on histopathology and related diseases.This article summarizes the recent research findings,in order to further clarify these issues.
关键词
脂滴/小胶质细胞/脂代谢/中枢神经系统疾病/炎症Key words
Lipid droplet/Microglia/Lipid metabolism/Central nervous system disorders/Inflammation引用本文复制引用
基金项目
国家自然科学基金(81971112)
江苏省自然科学基金(BK20191116)
出版年
2024
国家科技期刊平台
NSTL
万方数据