载脂蛋白E在阿尔茨海默病病理过程中的病理机制研究进展
Research advances in the pathological mechanism of apolipoprotein E in the pathological process of Alzheimer disease
马艺迅 1侯婷婷 1杜怡峰1
作者信息
- 1. 山东第一医科大学附属省立医院神经内科,山东 济南 250021
- 折叠
摘要
阿尔茨海默病(AD)是以认知功能减退为特征的老年人常见的神经系统变性疾病,是导致老年人痴呆最常见的病因.目前阿尔茨海默病发病机制尚不明确,尚无针对病因的治疗手段.载脂蛋白E(APOE)是目前唯一公认的AD风险基因,其编码的ApoE蛋白在β淀粉样蛋白(Aβ)沉积、tau蛋白的过度磷酸化和神经炎症反应等AD病理发生过程中起到重要作用.本文就ApoE的结构、功能及其在AD发生的病理过程中的作用进行综述,为寻找AD新的干预靶点提供思路和方向.
Abstract
Alzheimer disease(AD)is a common neurodegenerative disease characterized by cognitive decline and is the most common cause of dementia in the elderly.At present,the pathogenesis of AD remains unclear,and there is still a lack of effective treatment methods for etiologies.Apolipoprotein E(APOE)is currently the only risk gene recog-nized for AD,and the ApoE protein encoded by ApoE plays an important role in the pathological processes of AD,such as amyloid β-protein deposition,excessive phosphorylation of tau protein,and neuroinflammatory reaction.This article re-views the structure and function of ApoE and its role in the pathological processes of AD,in order to provide ideas and di-rections for finding new intervention targets for AD.
关键词
阿尔茨海默病/载脂蛋白E/病理机制Key words
Alzheimer disease/Apoprotein E/Pathological mechanism引用本文复制引用
基金项目
山东省自然科学基金面上项目(ZR2021MH392)
中国"脑科学与类脑研究"重大项目(2021ZD0201801)
中国"脑科学与类脑研究"重大项目(2021ZD0201808)
出版年
2024
国家科技期刊平台
NSTL
万方数据