乳脂球表皮生长因子8与阿尔茨海默病的关联
Association between milk fat globule-epidermal growth factor 8 with Alzheimer disease
张子豪 1朱阳可 1王誉静 2马灵志 1谭兰1
作者信息
- 1. 青岛大学,青岛大学医学部,青岛市市立医院神经内科,山东 青岛 266071
- 2. 山东第二医科大学,山东第二医科大学临床医学院,山东 潍坊 261053
- 折叠
摘要
目的 探讨乳脂球表皮生长因子8(MFG-E8)与阿尔茨海默病(AD)的关联.方法 使用阿尔茨海默病神经影像计划数据库,多元线性回归用来研究MFG-E8与AD病理标志物以及脑结构的关联并进行亚组分析.使用混合效应模型研究MFG-E8与AD病理标志物和脑结构的纵向变化.中介分析用来研究MFG-E8与AD病理和脑结构之间的潜在关联.结果 一共377例纳入研究,MFG-E8水平与脑脊液中β淀粉样蛋白42(Aβ42),tau蛋白以及磷酸化tau蛋白(P-tau)浓度呈正相关,亚组分析结果显示,在男性、老年人以及携带APOE4基因的人群中,MFG-E8水平与AD病理标志物的浓度及侧脑室体积的大小关联与总体人群一致.纵向结果表明,在随访时间内,MFG-E8水平的升高与侧脑室体积扩大显著相关.此外,MFG-E8可通过影响Aβ42水平改变侧脑室体积.结论 MFG-E8与AD存在关联,可能通过AD病理标志物影响侧脑室体积变化.
Abstract
Objective To investigate the association between milk fat globule-epidermal growth factor 8(MFG-E8)and Alzheimer disease(AD).Methods The Alzheimer's Disease Neuroimaging Initiative database was used,and a multiple linear regression analysis was used to investigate the association of MFG-E8 with the pathological markers of AD and brain structure and perform subgroup analyses.The mixed-effects model was used to investigate the longitudinal changes in MFG-E8 with AD pathological markers and brain structure,and a mediation analysis was used to investigate the potential association of MFG-E8 with AD pathology and brain structure.Results A total of 377 individuals were en-rolled in the study.The level of MFG-E8 was positively correlated with the concentrations of amyloid β-protein 42(Aβ42),tau protein,and phosphorylated tau protein in cerebrospinal fluid,and subgroup analyses showed that the correlation of MFG-E8 with the concentrations of AD pathological markers and lateral ventricular volume in male individuals,the elderly popula-tion,and the individuals carrying the APOE4 gene was consistent with that in the overall population.Longitudinal studies showed that during follow-up,the increase in MFG-E8 level was significantly associated with enlarged lateral ventricle volume.In addition,MFG-E8 could alter lateral ventricle volume by affecting the level of Aβ42.Conclusion MFG-E8 is associated with AD and may influence lateral ventricular volume through AD pathological markers.
关键词
乳脂球表皮生长因子8/阿尔茨海默病/痴呆/β淀粉样蛋白42Key words
Milk fat globule-epidermal growth factor 8/Alzheimer disease/Dementia/Amyloid β-protein 42引用本文复制引用
基金项目
国家自然科学基金(82271475)
国家自然科学基金(82201587)
出版年
2024
国家科技期刊平台
NSTL
万方数据