低强度聚焦超声活化小胶质细胞治疗阿尔茨海默病的动物研究进展
Advances in animal studies on the activation of microglial cells by low-intensity focused ultrasound in treatment of Alzheimer disease
李硕 1刘焕亮 2崔慧娟 2曹慧 2付源3
作者信息
- 1. 哈尔滨医科大学附属第四医院超声科,黑龙江 哈尔滨 150001
- 2. 哈尔滨医科大学附属第四医院神经内科,黑龙江 哈尔滨 150001
- 3. 哈尔滨医科大学附属第四医院神经内科,黑龙江 哈尔滨 150001;浙江大学医学院附属第一医院神经内科,浙江 杭州 310003
- 折叠
摘要
阿尔茨海默病(AD)是老年人群中常见的神经系统变性疾病,以淀粉样斑块异常蓄积为典型病理特征.血脑屏障因其严格的选择透过性阻止一切大分子物质进入中枢神经系统,成为向脑内输送治疗药物的"瓶颈".研究发现,低强度聚焦超声结合超声微泡可通过空化作用安全可逆地打开血脑屏障内皮细胞间隙,并通过促进小胶质细胞向抗炎状态活化减轻淀粉样蛋白沉积.本综述旨在深入剖析低强度聚焦超声在治疗AD中的最新研究进展,为AD的治疗提供理论基础和新策略.
Abstract
Alzheimer disease is a common neurodegenerative disease among the elderly and has abnormal accumula-tion of amyloid plaques as the typical pathological feature.Because of its strict selective permeability,the blood-brain bar-rier prevents all macromolecular substances from entering the central nervous system and has thus become a"bottleneck"for delivering therapeutic drugs to the brain.Studies have shown that low-intensity focused ultrasound combined with ultra-sound microbubbles can safely and reversibly open the junction between endothelial cells of the blood-brain barrier through cavitation and reduce amyloid deposition by promoting the activation of microglial cells into an anti-inflammatory state.This article reviews the latest research advances in low-intensity focused ultrasound in the treatment of Alzheimer disease,in order to provide a theoretical basis and new strategies for the treatment of Alzheimer disease.
关键词
阿尔茨海默病/低强度聚焦超声/小胶质细胞/血脑屏障Key words
Alzheimer disease/Low-intensity focused ultrasound/Microglial cell/Blood-brain barrier引用本文复制引用
基金项目
黑龙江省自然科学基金联合引导项目(LH2021H036)
国家自然科学基金(81500917)
教育部"春晖计划"合作科研项目(HLJ2019012)
黑龙江省博士后科研启动基金(LBH-Q19033)
黑龙江省留学归国科学基金(LC2016033)
哈尔滨医科大学伍连德青年科学基金(WLD-QN1711)
浙江大学百人计划启动基金(B202306)
出版年
2024
国家科技期刊平台
NSTL
万方数据