Clinical characteristics of 23 children with epilepsia partialis continua
Objective To study the clinical manifestations of children with epilepsia partialis continua(EPC),and to improve the understanding of the treatment and prognosis of this disease.Methods We retrospectively analyzed the data of 23 patients with EPC at the Department of Pediatrics of Xuanwu Hospital of Capital Medical University from July 2017 to July 2022.The data included general information,clinical manifestations,electroencephalography(EEG)re-sults,and surgical and prognostic information.Results A total of 23 patients(15 males and 8 females)were included,with a mean age of onset of(5.1±3.0)years and a mean age of epileptic exposure of(6.0±3.5)years.Twenty-one pa-tients(91.3%)developed motor seizures of focal origin as the initial presentation.Eleven patients(47.8%)presented with hemiparesis at 0.3 to 3 years after disease onset.All the patients showed a slow rhythm of the affected hemisphere on EEG;and cerebral hemiatrophy was found in 11 cases,and hippocampal abnormalities were found in 13 cases.The me-tabolism of the affected hemisphere was decreased in all the 7 examinees.All the 9 examinees had decreased perfusion in different brain regions.Among 10 cases undergoing surgery,the mean age at the time of the operation was(7.7±3.4)years,and the mean duration of the disease at the time of the operation was(3.6±3.6)years;after surgery,7 cases were free from seizures;2 cases had remission,and 1 had no improvement.Conclusion EPC is common in preschool-age and school-age children,manifesting as slower rhythms and interictal epileptiform discharges in the affected hemisphere on EEG.The decreased perfusion of the brain may be linked to the development of EPC.Surgical treatment can alleviate sei-zures for patients with EPC.
国家科技期刊平台
NSTL
万方数据
