摘要
目的 评价2015-2020年江苏省部分农村地区丙戊酸钠单药治疗的惊厥性癫痫患者的效果.方法 对进入该组的惊厥癫痫患者开展丙戊酸钠单药治疗及跟踪管理.评价分析患者的临床特征、服药剂量、药物疗效以及不良反应等.结果 本研究入组惊厥性癫痫患者共195例,其中男性117例.48.72%的癫痫患者丙戊酸钠治疗最大服用剂量≤600 mg/d.193例患者随访满1年,治疗有效率为74.09%.79例患者随访满5年,累积治疗有效率增长至87.34%.随着疗程增加,不良反应发生率逐步下降,主观感觉病情改善的患者比例升高.结论 丙戊酸钠单药治疗效果显著,患者出现不良反应的程度较轻,可推荐用于农村惊厥性癫痫的治疗.
Abstract
Objective To investigate the efficacy of valproic acid monotherapy in patients with convulsive epilepsy in several rural areas of Jiangsu Province,China,in 2005-2020.Methods The patients with convulsive epilepsy were given valproic acid monotherapy and follow-up management,and they were analyzed in terms of clinical features,medica-tion dose,drug efficacy,and adverse reactions.Results A total of 195 patients with convulsive epilepsy were enrolled in this study,among whom there were 117 male patients.Among these patients,48.72%were treated with valproate acid at a maximum dose of≤600 mg/d.In this study,193 patients were followed up for 1 year,with a response rate of 74.09%,and 79 patients were followed up for 5 years,with a cumulative response rate increasing to 87.34%.The incidence rate of adverse reactions gradually decreased with the increase in the course of treatment,and there was an increase in the propor-tion of patients with a subjective feeling of improvement in their conditions.Conclusion Valproic acid monotherapy has a marked clinical effect with slight adverse reactions,and thus it can be widely used in the treatment of patients with con-vulsive epilepsy in rural areas.
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