Research progress on the prevention and treatment of early neurological deterioration after intravenous throm-bolysis with tirofiban
At present,for acute ischemic stroke patients with onset time within 4.5 hours,intravenous thrombolysis is the preferred method for early reperfusion,but early neurological deterioration is prone to occur within 24 hours after thrombolysis,which is mainly related to the progress of ischemia.Early use of antiplatelet drugs may prevent or improve early neurological deterioration,but traditional antiplatelet drugs have a slow effect and related studies have shown a risk of bleeding.It is recommended to apply after 24 hours.However,24 hours after thrombolysis is a high-risk period for neu-rological deterioration,so it is necessary to find an antiplatelet drug that can be applied within 24 hours.Some studies have found that early use of tirofiban after intravenous thrombolysis can prevent early neurological deterioration.At the same time,for patients who have already experienced earlyneurological deterioration,the use of tirofiban can effectively improve their long-term prognosis.This article will elaborate on the research progress of the application of tirofiban in the prevention and treatment of early neurological deterioration after intravenous thrombolysis.
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