Regulatory role and therapeutic effects of VEGF in intracerebral hemorrhage
In intracranial hemorrhage,the rupture of intracranial blood vessels results in elevated intracranial pres-sure and reduced cerebral blood flow and perfusion pressure,which directly impact blood oxygen supply to cause a series of brain injuries that are hard to recover.Angiogenesis has been demonstrated favorable for the prognosis of cerebral hem-orrhage.Vascular endothelial growth factor(VEGF)is regarded as a main regulator of angiogenesis and vasculogenesis,which can regulate the pathological mechanism of cerebral hemorrhage through multiple pathways.It can not only facilitate and mediate the formation of new blood vessels to enhance oxygen and nutrient supply in bleeding areas,but also protect neural cells through alleviating inflammation,inhibiting cell apoptosis,up-regulating trophic factors,and down-regulating toxic proteins.This review focuses on the regulatory role of VEGF in the pathological process of cerebral hemorrhage as well as its effects in the treatment of cerebral hemorrhage.
万方数据
维普
