Research advances on the role of peripheral immunity in the development and progression of Alzheimer disease
Alzheimer disease(AD),a degenerative disease of the central nervous system characterized by progres-sive cognitive dysfunction and behavioral impairment,has gradually become one of the most burdensome diseases in this century.At present,the amyloid cascade hypothesis is a widely recognized theory on the pathogenesis of AD.However,recent studies have shown that the immune system can play an important role in the occurrence of AD.This article summa-rizes the relationship between the immune system and the development and progression of AD from the existing literature,with an emphasis on the role of peripheral immunity in both the innate and adaptive immune systems,aiming to provide novel ideas for future research on AD in the immunological direction.
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