Effect of liver enzymes on association between metabolically healthy obesity and hyperuricemia in steelworkers
The association between MHO and HUA and whether liver enzyme abnormalities could modify this association were studied.The cross-sectional study was conducted using 6,868 steelworkers in Hebei Iron and Steel Company who participated in occupational medical examinations as the study population.The data were analyzed using logistic regression models and interaction effect model.The results show that,in a multiple adjusted logistic model,the risk of HUA is increased 2.13-fold(odds ratio(OR)= 2.13,95%confidence interval(CI):1.08-4.21)for metabolically healthy generalized obesity(MHGO).The risk of HUA is increased 2.25-fold(OR=2.25,95%CI:1.14-4.45)for metabolically healthy abdominal obesity(MHAO).In stratified analysis,in the group with elevated liver enzymes,the prevalence of HUA in steelworkers with MHO(MHGO and MHAO)is significantly higher than that in the group with normal liver enzymes,and the interaction between obesity phenotypes and liver enzyme levels has a statistically significant effect on HUA(P＜0.05).MHO is associated with a high prevalence of HUA.Liver enzyme levels may alter the relationship between MHO and HUA.
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